Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000955)
Formula
SVG example
O-Dealkylation
Reactant Esomeprazole Product 5-O-Desmethylomeprazole
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - O-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000956 Esomeprazole 5-hydroxyomeprazole Oxidation - 5-Hydroxylation Esomeprazole [1]
MR000953 Esomeprazole Active metabolite of Esomeprazole Unclear Esomeprazole [2]
MR000954 Esomeprazole Omeprazole sulfone metabolite Oxidation - S-Oxidation Esomeprazole [3], [1]
References
1 Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole Clin Pharmacokinet. 2001;40(6):411-26. doi: 10.2165/00003088-200140060-00003.
2 DrugBank(Pharmacology-Metabolism)Esomeprazole
3 Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.