Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000954)
Formula
SVG example
S-Oxidation
Reactant Esomeprazole Product Omeprazole sulfone metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - S-Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000956 Esomeprazole 5-hydroxyomeprazole Oxidation - 5-Hydroxylation Esomeprazole [1]
MR000955 Esomeprazole 5-O-Desmethylomeprazole Oxidation - O-Dealkylation Esomeprazole [2]
MR000953 Esomeprazole Active metabolite of Esomeprazole Unclear Esomeprazole [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001829 Omeprazole Omeprazole sulfone metabolite Oxidation - Sulfoxidation Omeprazole [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001828 Omeprazole sulfone metabolite 5'-OH omeprazole sulfide metabolite Oxidation - Hydroxylation Omeprazole [4]
References
1 Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole Clin Pharmacokinet. 2001;40(6):411-26. doi: 10.2165/00003088-200140060-00003.
2 Expression, activity and regulation of CYP3A in human and rodent brain Drug Metab Rev. 2008;40(1):149-68. doi: 10.1080/03602530701836712.
3 DrugBank(Pharmacology-Metabolism)Esomeprazole
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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