Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000984)
Formula
SVG example
Glucuronidation
Reactant Etoposide Product Etoposide glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000983 Etoposide 3'-demethyletoposide Oxidation - 3'-Demethylation Etoposide [1]
MR000982 Etoposide Etoposide catechol Unclear Etoposide [2]
References
1 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
2 Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation. Biochem Pharmacol. 1992 Apr 15;43(8):1761-8.

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