Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000983)
Formula
SVG example
3'-Demethylation
Reactant Etoposide Product 3'-demethyletoposide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - 3'-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000982 Etoposide Etoposide catechol Unclear Etoposide [1]
MR000984 Etoposide Etoposide glucuronide Conjugation - Glucuronidation Etoposide [2]
References
1 Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation. Biochem Pharmacol. 1992 Apr 15;43(8):1761-8.
2 DrugBank(Pharmacology-Metabolism)Etoposide

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