Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000982)
Formula
CYP3A4 ...
SVG example
Reactant Etoposide Product Etoposide catechol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000983 Etoposide 3'-demethyletoposide Oxidation - 3'-Demethylation Etoposide [1]
MR000984 Etoposide Etoposide glucuronide Conjugation - Glucuronidation Etoposide [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000981 Etoposide catechol Etoposide ortho-quinone Unclear Etoposide [2]
References
1 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
2 DrugBank(Pharmacology-Metabolism)Etoposide

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