Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001046)
Formula Reactant Fingolimod hydrochloride Product (S)-enantiomer of fingolimod-phosphate
Reactant Info Product Info
Metabolic Enzyme Sphingosine kinase 1 (SPHK1) DME Info
Metabolic Type Other reaction - Phosphorylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001048 Fingolimod hydrochloride . Unclear Fingolimod hydrochloride [1]
MR001045 Fingolimod hydrochloride Fingolimod carboxylic acid metabolite Oxidation - Hydroxylation Fingolimod hydrochloride [2]
MR001047 Fingolimod hydrochloride Non-polar ceramides analogs of fingolimod Unclear Fingolimod hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001041 Fingolimod (S)-enantiomer of fingolimod-phosphate Other reaction - Phosphorylation Fingolimod [2], [3]
References
1 LABEL:INGOLIMOD capsule
2 Clinical pharmacokinetics of fingolimod Clin Pharmacokinet. 2012 Jan 1;51(1):15-28. doi: 10.2165/11596550-000000000-00000.
3 Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition J Clin Pharmacol. 2009 Feb;49(2):212-8. doi: 10.1177/0091270008329553.

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