Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001045)
Formula Reactant Fingolimod hydrochloride Product Fingolimod carboxylic acid metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 4F2 (CYP4F2) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001046 Fingolimod hydrochloride (S)-enantiomer of fingolimod-phosphate Other reaction - Phosphorylation Fingolimod hydrochloride [1], [2]
MR001048 Fingolimod hydrochloride . Unclear Fingolimod hydrochloride [3]
MR001047 Fingolimod hydrochloride Non-polar ceramides analogs of fingolimod Unclear Fingolimod hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001040 Fingolimod Fingolimod carboxylic acid metabolite Oxidation - Hydroxylation Fingolimod [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001039 Fingolimod carboxylic acid metabolite . Oxidation - Oxidation Fingolimod [4]
MR001044 Fingolimod carboxylic acid metabolite . Oxidation - Oxidation Fingolimod hydrochloride [4]
References
1 Clinical pharmacokinetics of fingolimod Clin Pharmacokinet. 2012 Jan 1;51(1):15-28. doi: 10.2165/11596550-000000000-00000.
2 Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition J Clin Pharmacol. 2009 Feb;49(2):212-8. doi: 10.1177/0091270008329553.
3 LABEL:INGOLIMOD capsule
4 CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis. Drug Metab Dispos. 2011 Feb;39(2):191-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.