Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001193)
Formula
SVG example
Hydroxylation
Reactant Indinavir sulfate Product Indinavir sulfate metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001194 Indinavir sulfate Indinavir sulfate metabolite M1 Conjugation - Glucuronidation Indinavir sulfate [1]
MR001191 Indinavir sulfate Indinavir sulfate metabolite M4a Oxidation - Oxidation Indinavir sulfate [1]
MR001195 Indinavir sulfate Indinavir sulfate metabolite M4b Oxidation - Hydroxylation Indinavir sulfate [1]
MR001192 Indinavir sulfate Indinavir sulfate metabolite M6 Oxidation - N-Depyridomethylation Indinavir sulfate [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001190 Indinavir sulfate metabolite M3 Indinavir sulfate metabolite M3 Oxidation - Oxidation Indinavir sulfate [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001190 Indinavir sulfate metabolite M3 Indinavir sulfate metabolite M3 Oxidation - Oxidation Indinavir sulfate [1]
MR001189 Indinavir sulfate metabolite M3 Indinavir sulfate metabolite M5 Oxidation - N-Depyridomethylation Indinavir sulfate [1]
References
1 Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A. Biochem Pharmacol. 1997 Apr 25;53(8):1187-95.
2 Involvement of CYP3A4 and MDR1 in altered metabolism and transport of indinavir in 1,25(OH)(2)D(3)-treated Caco-2 cells. Eur J Pharm Sci. 2023 Apr 1;183:106396. doi: 10.1016/j.ejps.2023.106396.

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