Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001195)
Formula
SVG example
Hydroxylation
Reactant Indinavir sulfate Product Indinavir sulfate metabolite M4b
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001194 Indinavir sulfate Indinavir sulfate metabolite M1 Conjugation - Glucuronidation Indinavir sulfate [1]
MR001193 Indinavir sulfate Indinavir sulfate metabolite M3 Oxidation - Hydroxylation Indinavir sulfate [1]
MR001191 Indinavir sulfate Indinavir sulfate metabolite M4a Oxidation - Oxidation Indinavir sulfate [1]
MR001192 Indinavir sulfate Indinavir sulfate metabolite M6 Oxidation - N-Depyridomethylation Indinavir sulfate [1], [2]
References
1 Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A. Biochem Pharmacol. 1997 Apr 25;53(8):1187-95.
2 Involvement of CYP3A4 and MDR1 in altered metabolism and transport of indinavir in 1,25(OH)(2)D(3)-treated Caco-2 cells. Eur J Pharm Sci. 2023 Apr 1;183:106396. doi: 10.1016/j.ejps.2023.106396.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.