General Information of This Metabolic Reaction (MR) (ID: MR001226)
Formula
CES1 ...
SVG example
Reactant Irinotecan hydrochloride Product SN-38
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Carboxylesterase 2 (CES2) DME Info
Butyrylcholine esterase (BCHE) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001224 Irinotecan hydrochloride 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin Unclear Irinotecan hydrochloride [1], [2]
MR001225 Irinotecan hydrochloride NPC Unclear Irinotecan hydrochloride [1], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013226 Sacituzumab govitecan SN-38 Other reaction - Cleavage Sacituzumab govitecan [5]
MR005887 SN-38G SN-38 Unclear SN-38G [6]
MR012144 Irinotecan SN-38 Unclear - Unclear Etirinotecan pegol [7]
MR013626 T-2513 SN-38 Unclear T-0128 [8]
References
1 Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients Drug Metab Dispos. 2000 Apr;28(4):423-33.
2 Effect of UGT1A1, CYP3A and CES Activities on the Pharmacokinetics of Irinotecan and its Metabolites in Patients with UGT1A1 Gene Polymorphisms. Eur J Drug Metab Pharmacokinet. 2021 Mar;46(2):317-324. doi: 10.1007/s13318-021-00675-3.
3 Structural insights into catalytical capability for CPT11 hydrolysis and substrate specificity of a novel marine microbial carboxylesterase, E93. Front Microbiol. 2023 Jan 11;13:1081094. doi: 10.3389/fmicb.2022.1081094.
4 Population pharmacokinetic model of irinotecan and its four main metabolites in patients treated with FOLFIRI or FOLFIRINOX regimen. Cancer Chemother Pharmacol. 2021 Aug;88(2):247-258. doi: 10.1007/s00280-021-04255-9.
5 Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
6 The gut microbiome: an orchestrator of xenobiotic metabolism
7 Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors
8 Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

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