Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012144)
Formula
ES
SVG example
Unclear
Reactant Irinotecan Product SN-38
Reactant Info Product Info
Metabolic Enzyme Esterases (ES) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012143 Etirinotecan pegol Irinotecan Hydrolysis - Hydrolysis Etirinotecan pegol [1]
MR014205 NUC?1031 Gemcitabine Hydrolysis - Hydrolyzation acelarin [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012146 Irinotecan APC,NPC Oxidation - Oxidation Etirinotecan pegol [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001226 Irinotecan hydrochloride SN-38 Unclear Irinotecan hydrochloride [3], [4], [5]
MR013226 Sacituzumab govitecan SN-38 Other reaction - Cleavage Sacituzumab govitecan [6]
MR005887 SN-38G SN-38 Unclear SN-38G [7]
MR013626 T-2513 SN-38 Unclear T-0128 [8]
References
1 Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors
2 Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study
3 Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients Drug Metab Dispos. 2000 Apr;28(4):423-33.
4 Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model. Br J Pharmacol. 2023 May;180(10):1362-1378. doi: 10.1111/bph.16020.
5 UHPLC-MS/MS method for the quantification of ultra-traces of irinotecan and its metabolites in red blood cells and plasma to detect caregivers' contamination. Drug Test Anal. 2023 Jun 28. doi: 10.1002/dta.3539.
6 Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
7 The gut microbiome: an orchestrator of xenobiotic metabolism
8 Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

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