Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013226)
Formula
SVG example
Cleavage
Reactant Sacituzumab govitecan Product SN-38
Reactant Info Product Info
Metabolic Type Other reaction - Cleavage
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001226 Irinotecan hydrochloride SN-38 Unclear Irinotecan hydrochloride [1], [2], [3]
MR005887 SN-38G SN-38 Unclear SN-38G [4]
MR012144 Irinotecan SN-38 Unclear - Unclear Etirinotecan pegol [5]
MR013626 T-2513 SN-38 Unclear T-0128 [6]
References
1 Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients Drug Metab Dispos. 2000 Apr;28(4):423-33.
2 Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model. Br J Pharmacol. 2023 May;180(10):1362-1378. doi: 10.1111/bph.16020.
3 UHPLC-MS/MS method for the quantification of ultra-traces of irinotecan and its metabolites in red blood cells and plasma to detect caregivers' contamination. Drug Test Anal. 2023 Jun 28. doi: 10.1002/dta.3539.
4 The gut microbiome: an orchestrator of xenobiotic metabolism
5 Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors
6 Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

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