Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005887)
Formula
GUS
SVG example
Reactant SN-38G Product SN-38
Reactant Info Product Info
Metabolic Enzyme microbiome -glucuronidases (GUS) DME Info
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001226 Irinotecan hydrochloride SN-38 Unclear Irinotecan hydrochloride [1], [2], [3]
MR013226 Sacituzumab govitecan SN-38 Other reaction - Cleavage Sacituzumab govitecan [4]
MR012144 Irinotecan SN-38 Unclear - Unclear Etirinotecan pegol [5]
MR013626 T-2513 SN-38 Unclear T-0128 [6]
References
1 Pharmacokinetics, metabolism, and excretion of irinotecan (CPT-11) following I.V. infusion of [(14)C]CPT-11 in cancer patients Drug Metab Dispos. 2000 Apr;28(4):423-33.
2 Opioid-induced microbial dysbiosis disrupts irinotecan (CPT-11) metabolism and increases gastrointestinal toxicity in a murine model. Br J Pharmacol. 2023 May;180(10):1362-1378. doi: 10.1111/bph.16020.
3 UHPLC-MS/MS method for the quantification of ultra-traces of irinotecan and its metabolites in red blood cells and plasma to detect caregivers' contamination. Drug Test Anal. 2023 Jun 28. doi: 10.1002/dta.3539.
4 Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
5 Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors
6 Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.