Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001321)
Formula
CYP2C9 ...
SVG example
N-Demethylation
Reactant Ketamine Product Norketamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001324 Ketamine 4-hydroxyketamine Oxidation - Hydoxylation Ketamine [1], [2]
MR001323 Ketamine 5-hydroxyketamine Oxidation - Hydoxylation Ketamine [1], [2]
MR001322 Ketamine 6-hydroxyketamine Oxidation - Hydoxylation Ketamine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001313 Norketamine 4-hydroxynorketamine Oxidation - Hydoxylation Ketamine [1], [3]
MR001312 Norketamine 5-hydroxynorketamine Oxidation - Hydoxylation Ketamine [1], [3]
MR001311 Norketamine 6-hydroxynorketamine Oxidation - Hydoxylation Ketamine [1], [4], [3]
MR001314 Norketamine Dehydronorketamine Oxidation - Dehydrogenation Ketamine [1], [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Metabolism and metabolomics of ketamine: a toxicological approach. Forensic Sci Res. 2017 Feb 20;2(1):2-10.
3 The clinical toxicology of ketamine. Clin Toxicol (Phila). 2023 Jun;61(6):415-428. doi: 10.1080/15563650.2023.2212125.
4 Simultaneous quantitation of ketamine, norketamine and dehydronorketamine in human milk using a novel ultra high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) assay. J Pharm Biomed Anal. 2023 Jun 1;234:115502. doi: 10.1016/j.jpba.2023.115502.

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