Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001335)
Formula
SVG example
Reactant Ketobemidone Product Dihydroxy ketobemidone
Reactant Info Product Info
Metabolic Enzyme Prostaglandin G/H synthase 1 (COX-1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001338 Ketobemidone Ketobemidone N-oxide metabolite Oxidation - N-Oxidation Ketobemidone [1]
MR001336 Ketobemidone Norketobemidone Oxidation - N-Demethylation Ketobemidone [2], [3]
MR001337 Ketobemidone Reduced ketobemidone Reduction - Reduction Ketobemidone [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003315 Melatonin Dihydroxy ketobemidone Oxidation - O-Demethylation Melatonin [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001331 Dihydroxy ketobemidone M-hydroxymethoxy ketobemidone Unclear Ketobemidone [2]
MR003309 Dihydroxy ketobemidone N-Acetyl-5-hydroxytryptamine glucuronide metabolite Conjugation - Glucuronidation Melatonin [2]
MR003310 Dihydroxy ketobemidone N-Acetyl-5-hydroxytryptamine sulfate metabolite Other reaction - Sulfonation Melatonin [2]
MR001330 Dihydroxy ketobemidone p-hydroxymethoxy ketobemidone Unclear Ketobemidone [2]
References
1 Quantitative determination of the urinary excretion of ketobemidone and four of its metabolites after intravenous and oral administration in man Drug Metab Dispos. 1981 Jul-Aug;9(4):376-80.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96.
4 DrugBank(Pharmacology-Metabolism)Ketobemidone hydrochloride

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