Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001368)
Formula
CYP2C8 ...
SVG example
Hydroxylation
Reactant Ketorolac Product 4-hydroxy ketorolac
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001370 Ketorolac K1 Unclear Ketorolac [1]
MR001374 Ketorolac K2 Unclear Ketorolac [1]
MR001373 Ketorolac K6 Conjugation - Methylation Ketorolac [1]
MR001372 Ketorolac K7 Conjugation - Acetylation Ketorolac [1]
MR001371 Ketorolac K8 Conjugation - Sulfation Ketorolac [1]
MR001369 Ketorolac Rac Ketorolac glucuronide Conjugation - Glucuronidation Ketorolac [1]
References
1 Identification and structural characterization of in vivo metabolites of ketorolac using liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) J Mass Spectrom. 2012 Jul;47(7):919-31. doi: 10.1002/jms.3043.

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