Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001447)
Formula Reactant Letrozole Product Letrozole ketone analog metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2A6 (CYP2A6) DME Info
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001445 Letrozole ketone analog metabolite 4,4'-methanol-bisbenzonitrile Unclear Letrozole [1]
References
1 Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer Chemother Pharmacol. 2009 Oct;64(5):867-75.

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