Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000081)
Formula
SVG example
Reactant Adenosine phosphate metabolite IMP Product Inosine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000082 Adenosine phosphate Adenosine phosphate metabolite IMP Unclear Adenosine phosphate [1], [2]
MR007514 Inosine IMP Unclear Inosine [3], [4]
MR011568 ZMP IMP Unclear - Unclear Acadesine [5]
MR004026 GMP IMP Unclear Xanthine [6]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011569 IMP AMP Unclear - Unclear Acadesine [5]
MR004027 IMP SAMP Unclear Xanthine [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000077 Adenosine Inosine Oxidation - Deamination Adenosine [7], [2]
MR001474 Levocarnitine Inosine Oxidation - Deamination Levocarnitine [8]
MR002342 Tasimelteon Inosine Oxidation - Hydroxylation Tasimelteon [9]
References
1 Condition-dependent adenosine monophosphate decomposition pathways in striated adductor muscle from Japanese scallop (Patinopecten yessoensis) J Food Sci. 2020 May;85(5):1462-1469. doi: 10.1111/1750-3841.15142.
2 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
3 Metabolism of nicotinamide, adenine and inosine in developing microspore-derived canola (Brassica napus) embryos
4 Inosine in Biology and Disease
5 A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy
6 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism
7 DrugBank(Pharmacology-Metabolism)Adenosine
8 Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. J Struct Biol. 2004 Jun;146(3):416-24.
9 Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist. J Clin Pharmacol. 2015 Sep;55(9):1004-11.

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