Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002342)
Formula
CYP1A2 ...
SVG example
Hydroxylation
Reactant Tasimelteon Product Inosine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002340 Tasimelteon Tasimelteon metabolite M13 Oxidation - Hydroxylation Tasimelteon [1]
MR002341 Tasimelteon Tasimelteon metabolite M14 Oxidation - Hydroxylation Tasimelteon [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000077 Adenosine Inosine Oxidation - Deamination Adenosine [2], [3]
MR001474 Levocarnitine Inosine Oxidation - Deamination Levocarnitine [4]
MR000081 Adenosine phosphate metabolite IMP Inosine Unclear Adenosine phosphate [5], [3]
References
1 Clinical assessment of drug-drug interactions of tasimelteon, a novel dual melatonin receptor agonist. J Clin Pharmacol. 2015 Sep;55(9):1004-11.
2 DrugBank(Pharmacology-Metabolism)Adenosine
3 Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data. Front Mol Neurosci. 2023 Feb 3;16:1089871. doi: 10.3389/fnmol.2023.1089871.
4 Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase. J Struct Biol. 2004 Jun;146(3):416-24.
5 Condition-dependent adenosine monophosphate decomposition pathways in striated adductor muscle from Japanese scallop (Patinopecten yessoensis) J Food Sci. 2020 May;85(5):1462-1469. doi: 10.1111/1750-3841.15142.

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