Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001547)
Formula
SVG example
Reactant Monoethylglycinexylidide Product 3-hydroxymonoethylglycinexylidide
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001550 Lidocaine Monoethylglycinexylidide Oxidation - N-De-Ethylation Lidocaine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001545 Monoethylglycinexylidide 2,6-xylidine Hydrolysis - Hydrolysis Lidocaine [2]
MR001546 Monoethylglycinexylidide Glycinexylidide Oxidation - Deamination Lidocaine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001549 3-hydroxylidocaine 3-hydroxymonoethylglycinexylidide Unclear Lidocaine [2]
References
1 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
2 The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders Headache. 2018 May;58(5):783-789. doi: 10.1111/head.13298.

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