Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001546)
Formula
SVG example
Deamination
Reactant Monoethylglycinexylidide Product Glycinexylidide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001550 Lidocaine Monoethylglycinexylidide Oxidation - N-De-Ethylation Lidocaine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001545 Monoethylglycinexylidide 2,6-xylidine Hydrolysis - Hydrolysis Lidocaine [2]
MR001547 Monoethylglycinexylidide 3-hydroxymonoethylglycinexylidide Unclear Lidocaine [2]
References
1 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
2 The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders Headache. 2018 May;58(5):783-789. doi: 10.1111/head.13298.

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