Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001550)
Formula
CYP1A2 ...
SVG example
N-De-Ethylation
Reactant Lidocaine Product Monoethylglycinexylidide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-De-Ethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001555 Lidocaine . Unclear Lidocaine [1]
MR001551 Lidocaine 2,6-xylidine Unclear Lidocaine [2], [3], [4]
MR001552 Lidocaine 3-hydroxylidocaine Oxidation - Hydroxylation Lidocaine [5]
MR001554 Lidocaine N-hydroxy-lidocaine Oxidation - Hydroxylation Lidocaine [5]
MR001553 Lidocaine NL-Ethyl-2-methyl-Nj-(2,6-dimethylphenyl)-4-imidazolidin Unclear Lidocaine [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001545 Monoethylglycinexylidide 2,6-xylidine Hydrolysis - Hydrolysis Lidocaine [5]
MR001547 Monoethylglycinexylidide 3-hydroxymonoethylglycinexylidide Unclear Lidocaine [5]
MR001546 Monoethylglycinexylidide Glycinexylidide Oxidation - Deamination Lidocaine [5]
References
1 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
2 Quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling J Pharm Sci. 1977 Aug;66(8):1180-90. doi: 10.1002/jps.2600660834.
3 An innovative nanoparticle-modified carbon paste sensor for ultrasensitive detection of lignocaine and its extremely carcinogenic metabolite residues in bovine food samples: Application of NEMI, ESA, AGREE, ComplexGAPI, and RGB12 algorithms. Food Chem. 2023 Jun 12;426:136579. doi: 10.1016/j.foodchem.2023.136579.
4 In vitro metabolism of lidocaine in subcellular post-mitochondrial fractions and precision cut slices from cattle liver. Toxicol In Vitro. 2021 Oct;76:105228. doi: 10.1016/j.tiv.2021.105228.
5 The Use and Method of Action of Intravenous Lidocaine and Its Metabolite in Headache Disorders Headache. 2018 May;58(5):783-789. doi: 10.1111/head.13298.

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