Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001720)
Formula
SVG example
Hydroxylation
Reactant Nelfinavir mesylate Product 3,4-Dihydroxynelfinavir
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001721 Nelfinavir mesylate 2-methoxy-3-hydroxynelfinavir Unclear Nelfinavir mesylate [1]
MR001719 Nelfinavir mesylate Nelfinavir hydroxyl-t- butylamide Oxidation - Hydroxylation Nelfinavir mesylate [2], [3]
References
1 Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19 Drug Metab Dispos. 2004 Dec;32(12):1462-7. doi: 10.1124/dmd.104.001743.
2 Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients Br J Clin Pharmacol. 2008 Apr;65(4):548-57. doi: 10.1111/j.1365-2125.2007.03039.x.
3 Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor Mol Pharmacol. 2021 Mar;99(3):184-196. doi: 10.1124/molpharm.120.000116.

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