Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001736)
Formula
CYP3A4 ...
SVG example
Reactant 2,6-dimethyl-4-(2-nitrophenyl)-5-methoxycarbonyl-pyridine-3-carboxylic acid Product 2-hydroxymethyl-pyridine carboxylic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001737 Nifedipine 2,6-dimethyl-4-(2-nitrophenyl)-5-methoxycarbonyl-pyridine-3-carboxylic acid Unclear Nifedipine [1]
MR001761 Nisoldipine Nisoldipine metabolite M1 Unclear Nisoldipine [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001758 Nisoldipine metabolite M1 Nisoldipine metabolite M2 Oxidation - Dehydrogenation Nisoldipine [2]
References
1 Pharmacokinetics and metabolism of nifedipine Hypertension. 1983 Jul-Aug;5(4 Pt 2):II18-24. doi: 10.1161/01.hyp.5.4_pt_2.ii18.
2 Clinical pharmacokinetics of nisoldipine coat-core Clin Pharmacokinet. 1998 Sep;35(3):191-208. doi: 10.2165/00003088-199835030-00003.

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