Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001758)
Formula
SVG example
Dehydrogenation
Reactant Nisoldipine metabolite M1 Product Nisoldipine metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Dehydrogenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001737 Nifedipine 2,6-dimethyl-4-(2-nitrophenyl)-5-methoxycarbonyl-pyridine-3-carboxylic acid Unclear Nifedipine [1]
MR001761 Nisoldipine Nisoldipine metabolite M1 Unclear Nisoldipine [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001736 2,6-dimethyl-4-(2-nitrophenyl)-5-methoxycarbonyl-pyridine-3-carboxylic acid 2-hydroxymethyl-pyridine carboxylic acid Unclear Nifedipine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009739 Furnidipine Furnidipine M-2 Unclear - Unclear Furnidipine [4], [5]
MR001757 Nisoldipine metabolite M13 Nisoldipine metabolite M2 Unclear Nisoldipine [6]
References
1 Pharmacokinetics and metabolism of nifedipine Hypertension. 1983 Jul-Aug;5(4 Pt 2):II18-24. doi: 10.1161/01.hyp.5.4_pt_2.ii18.
2 Clinical pharmacokinetics of nisoldipine coat-core Clin Pharmacokinet. 1998 Sep;35(3):191-208. doi: 10.2165/00003088-199835030-00003.
3 CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteers Pharmacogenomics J. 2004;4(1):34-9. doi: 10.1038/sj.tpj.6500218.
4 Dihydropyridines' metabolites-induced early apoptosis after myocardial infarction in rats; new outlook on preclinical study with M-2 and M-3
5 Cardioprotective effects of an active metabolite of furnidipine in 2 models of isolated heart and on in vivo ischemiaCinduced and reperfusion-induced arrhythmias in rats
6 Pharmacokinetics and metabolism of nilutamide Urology. 1991;37(2 Suppl):13-9. doi: 10.1016/0090-4295(91)80096-p.

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