Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001794)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Desmethylnortriptyline Product E-10-hydroxydesmethylnortriptyline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001796 Nortriptyline hydrochloride Desmethylnortriptyline Unclear Nortriptyline hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001795 E-10-hydroxydesmethylnortriptyline Oxonortriptyline Conjugation - Glycine Conjugation Nortriptyline hydrochloride [3], [2]
References
1 Quantitative Modeling Analysis Demonstrates the Impact of CYP2C19 and CYP2D6 Genetic Polymorphisms on the Pharmacokinetics of Amitriptyline and Its Metabolite, Nortriptyline J Clin Pharmacol. 2019 Apr;59(4):532-540. doi: 10.1002/jcph.1344.
2 DrugBank(Pharmacology-Metabolism)Nortriptyline hydrochloride
3 A novel LC-MS/MS method for simultaneous estimation of obeticholic acid, glyco-obeticholic acid, tauro-obeticholic acid in human plasma and its application to a pharmacokinetic study J Sep Sci. 2021 Apr;44(7):1307-1323. doi: 10.1002/jssc.202001050.

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