Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001796)
Formula
CYP1A2 ...
SVG example
Reactant Nortriptyline hydrochloride Product Desmethylnortriptyline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001794 Desmethylnortriptyline E-10-hydroxydesmethylnortriptyline Oxidation - N-Demethylation Nortriptyline hydrochloride [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacokinetics of nortriptyline and its 10-hydroxy metabolite in Chinese subjects of different CYP2D6 genotypes Clin Pharmacol Ther. 1998 Oct;64(4):384-90. doi: 10.1016/S0009-9236(98)90069-8.

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