Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001812)
Formula
CYP3A4 ...
SVG example
Alcohol Oxidation
Reactant Olaparib metabolite M10 Product Olaparib metabolite M12
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Alcohol Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001814 Olaparib Olaparib metabolite M10 Oxidation - Hydroxylation Olaparib [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001811 Olaparib metabolite M10 Olaparib metabolite M4 Oxidation - Dehydrogenation Olaparib [1]
References
1 In vitro metabolism of olaparib in liver microsomes by liquid chromatography/electrospray ionization high-resolution mass spectrometry Rapid Commun Mass Spectrom. 2020 Feb 15;34(3):e8575. doi: 10.1002/rcm.8575.

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