Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001830)
Formula
CYP3A4 ...
SVG example
5-Hydroxylation
Reactant Omeprazole Product 5-hydroxyomeprazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 5-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001832 Omeprazole 3-hydroxyomeprazole Oxidation - 3-Hydroxylation Omeprazole [1]
MR001831 Omeprazole 5'-O-Desmethyl omeprazole Oxidation - 5'-O-Demethylation Omeprazole [1]
MR001829 Omeprazole Omeprazole sulfone metabolite Oxidation - Sulfoxidation Omeprazole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000956 Esomeprazole 5-hydroxyomeprazole Oxidation - 5-Hydroxylation Esomeprazole [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole Clin Pharmacokinet. 2001;40(6):411-26. doi: 10.2165/00003088-200140060-00003.

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