Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001829)
Formula
SVG example
Sulfoxidation
Reactant Omeprazole Product Omeprazole sulfone metabolite
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Sulfoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001832 Omeprazole 3-hydroxyomeprazole Oxidation - 3-Hydroxylation Omeprazole [1]
MR001831 Omeprazole 5'-O-Desmethyl omeprazole Oxidation - 5'-O-Demethylation Omeprazole [1]
MR001830 Omeprazole 5-hydroxyomeprazole Oxidation - 5-Hydroxylation Omeprazole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000954 Esomeprazole Omeprazole sulfone metabolite Oxidation - S-Oxidation Esomeprazole [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001828 Omeprazole sulfone metabolite 5'-OH omeprazole sulfide metabolite Oxidation - Hydroxylation Omeprazole [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704.
3 Pharmacokinetic studies with esomeprazole, the (S)-isomer of omeprazole Clin Pharmacokinet. 2001;40(6):411-26. doi: 10.2165/00003088-200140060-00003.

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