Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001832)
Formula
SVG example
3-Hydroxylation
Reactant Omeprazole Product 3-hydroxyomeprazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - 3-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001831 Omeprazole 5'-O-Desmethyl omeprazole Oxidation - 5'-O-Demethylation Omeprazole [1]
MR001830 Omeprazole 5-hydroxyomeprazole Oxidation - 5-Hydroxylation Omeprazole [1]
MR001829 Omeprazole Omeprazole sulfone metabolite Oxidation - Sulfoxidation Omeprazole [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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