Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001867)
Formula
SVG example
Oxidation
Reactant R-licarbazepine Product Trans-10,11-dihydro-10,11-dihydroxycarbamazepine
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001872 Oxcarbazepine R-licarbazepine Reduction - Reduction Oxcarbazepine [1]
MR000950 Oxcarbazepine R-licarbazepine Reduction - Reduction Eslicarbazepine acetate [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001866 R-licarbazepine Cis-10,11-Dihydroxy-10,11-dihydrocarbamazepine Oxidation - Oxidation Oxcarbazepine [3]
MR001865 R-licarbazepine R-Licarbazepine glucuronide Conjugation - O-Glucuronidation Oxcarbazepine [3]
MR001868 R-licarbazepine S-Licarbazepine glucuronide Conjugation - O-Glucuronidation Oxcarbazepine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002584 10,11-Epoxycarbamazepine 10,11-Dihydroxycarbamazepine Unclear Carbamazepine [4]
References
1 The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7.
2 U. S. FDA Label -Eslicarbazepine acetate
3 DrugBank(Pharmacology-Metabolism)Oxcarbazepine
4 Carbamazepine and its metabolites in human perfused placenta and in maternal and cord blood Epilepsia. 1995 Mar;36(3):241-8. doi: 10.1111/j.1528-1157.1995.tb00991.x.

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