Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001875)
Formula
SVG example
Reactant Oxtriphylline Product 3-Methylxanthine
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001874 Oxtriphylline 1,3-Dimethyluric acid Unclear Oxtriphylline [1]
MR001873 Oxtriphylline 1-Methyluric acid Unclear Oxtriphylline [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006449 SC-15090 3-MX Oxidation - N3-demethylation SC-15090 [2]
MR004946 Theophylline 3-methylxanthine Oxidation - 1-N-demethylation Theophylline [3]
References
1 Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma Clin Pharmacol Ther. 2003 May;73(5):468-74. doi: 10.1016/s0009-9236(03)00013-4.
2 Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305.
3 Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7.

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