Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004946)
Formula
SVG example
1-N-demethylation
Reactant Theophylline Product 3-methylxanthine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Metabolic Type Oxidation - 1-N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004947 Theophylline 1,3-dimethyluric acid Oxidation - 8-hydroxylation Theophylline [1]
MR004944 Theophylline 1-Methylxanthine Oxidation - 3-N-demethylation Theophylline [1]
MR004948 Theophylline Caffeine Unclear Theophylline [2]
MR000547 Theophylline 1-Methylxanthine Oxidation - 3-N-Demethylation Caffeine [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001875 Oxtriphylline 3-Methylxanthine Unclear Oxtriphylline [5]
MR006449 SC-15090 3-MX Oxidation - N3-demethylation SC-15090 [6]
References
1 Theophylline metabolism in human liver microsomes: inhibition studies. J Pharmacol Exp Ther. 1996 Mar;276(3):912-7.
2 Metabolism of theophylline to caffeine in human fetal liver
3 In vivo evaluation of CYP1A2, CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios Biomed Chromatogr. 2007 Feb;21(2):190-200. doi: 10.1002/bmc.736.
4 Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. Nutr Res. 2023 Jan;109:12-25. doi: 10.1016/j.nutres.2022.11.002.
5 Polymorphisms in the CYP1A2 gene and theophylline metabolism in patients with asthma Clin Pharmacol Ther. 2003 May;73(5):468-74. doi: 10.1016/s0009-9236(03)00013-4.
6 Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305.

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