Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001881)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Oxycodone hydrochloride Product Noroxycodone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001883 Oxycodone hydrochloride 6beta-Oxycodol Reduction - Reduction Oxycodone hydrochloride [1]
MR001882 Oxycodone hydrochloride Alpha-Oxycodol Reduction - Reduction Oxycodone hydrochloride [1]
MR001884 Oxycodone hydrochloride Oxymorphone Oxidation - O-Demethylation Oxycodone hydrochloride [1], [2], [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013818 Oxycodone Noroxycodone Unclear - Unclear Oxycodone [5]
MR001899 Oxymorphone Noroxycodone Oxidation - N-Demethylation Oxymorphone [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001880 Noroxycodone Beta-Noroxycodol Reduction - 6-Ketoreduction Oxycodone hydrochloride [7]
MR001879 Noroxycodone Nor-6alpha-Oxycodol Reduction - 6-Ketoreduction Oxycodone hydrochloride [7]
MR001878 Noroxycodone Noroxymorphone Oxidation - N-Demethylation Oxycodone hydrochloride [1], [8]
MR013819 Noroxycodone Noroxymorphone Unclear - Unclear Oxycodone [5]
References
1 Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54.
2 Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward. J Pharmacol Exp Ther. 2022 Aug;382(2):167-180. doi: 10.1124/jpet.122.001217.
3 Impact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests. Pharmacogenomics J. 2022 Feb;22(1):25-32. doi: 10.1038/s41397-021-00253-5.
4 Association of CYP2D6 genotype predicted phenotypes with oxycodone requirements and side effects in children undergoing surgery. Ann Transl Med. 2022 Dec;10(23):1262. doi: 10.21037/atm-2022-58.
5 Metabolism and Disposition of Prescription Opioids: A Review
6 Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87.
7 DrugBank(Pharmacology-Metabolism)Oxycodone hydrochloride
8 Enzalutamide Reduces Oxycodone Exposure in Men with Prostate Cancer. Clin Pharmacokinet. 2023 May 10. doi: 10.1007/s40262-023-01255-1.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.