Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001899)
Formula
SVG example
N-Demethylation
Reactant Oxymorphone Product Noroxycodone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001903 Oxymorphone 6beta-Oxycodol Reduction - 6-Ketoreduction Oxymorphone [1]
MR001904 Oxymorphone 6beta-Oxymorphol Oxidation - N-Demethylation Oxymorphone [1]
MR001902 Oxymorphone Alpha-Oxycodol Reduction - 6-Ketoreduction Oxymorphone [1]
MR001901 Oxymorphone Beta-noroxycodol Oxidation - N-Demethylation Oxymorphone [1]
MR001900 Oxymorphone Nor-6alpha-Oxycodol Oxidation - N-Demethylation Oxymorphone [1]
MR001898 Oxymorphone Noroxymorphone Oxidation - N-Demethylation Oxymorphone [1]
MR001905 Oxymorphone Oxymorphone Oxidation - O-Demethylation Oxymorphone [1]
MR001887 Oxymorphone 6beta-Oxymorphol Reduction - 6-Ketoreduction Oxycodone hydrochloride [2]
MR001885 Oxymorphone Hydromorphinol Reduction - 6-Ketoreduction Oxycodone hydrochloride [2]
MR001886 Oxymorphone Noroxymorphone Oxidation - N-Demethylation Oxycodone hydrochloride [2]
MR013821 Oxymorphone Noroxymorphone Unclear - Unclear Oxycodone [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013818 Oxycodone Noroxycodone Unclear - Unclear Oxycodone [3]
MR001881 Oxycodone hydrochloride Noroxycodone Oxidation - N-Demethylation Oxycodone hydrochloride [4], [5], [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001880 Noroxycodone Beta-Noroxycodol Reduction - 6-Ketoreduction Oxycodone hydrochloride [2]
MR001879 Noroxycodone Nor-6alpha-Oxycodol Reduction - 6-Ketoreduction Oxycodone hydrochloride [2]
MR001878 Noroxycodone Noroxymorphone Oxidation - N-Demethylation Oxycodone hydrochloride [4], [5]
MR013819 Noroxycodone Noroxymorphone Unclear - Unclear Oxycodone [3]
References
1 Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87.
2 DrugBank(Pharmacology-Metabolism)Oxycodone hydrochloride
3 Metabolism and Disposition of Prescription Opioids: A Review
4 Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54.
5 Enzalutamide Reduces Oxycodone Exposure in Men with Prostate Cancer. Clin Pharmacokinet. 2023 May 10. doi: 10.1007/s40262-023-01255-1.
6 Impact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests. Pharmacogenomics J. 2022 Feb;22(1):25-32. doi: 10.1038/s41397-021-00253-5.

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