Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001878)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Noroxycodone Product Noroxymorphone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013818 Oxycodone Noroxycodone Unclear - Unclear Oxycodone [1]
MR001881 Oxycodone hydrochloride Noroxycodone Oxidation - N-Demethylation Oxycodone hydrochloride [2], [3], [4]
MR001899 Oxymorphone Noroxycodone Oxidation - N-Demethylation Oxymorphone [5]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001880 Noroxycodone Beta-Noroxycodol Reduction - 6-Ketoreduction Oxycodone hydrochloride [6]
MR001879 Noroxycodone Nor-6alpha-Oxycodol Reduction - 6-Ketoreduction Oxycodone hydrochloride [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010785 Naloxone Naloxone Metabolite M2 Unclear - Unclear Naloxone [7]
MR001898 Oxymorphone Noroxymorphone Oxidation - N-Demethylation Oxymorphone [5]
MR001886 Oxymorphone Noroxymorphone Oxidation - N-Demethylation Oxycodone hydrochloride [6]
MR013821 Oxymorphone Noroxymorphone Unclear - Unclear Oxycodone [1]
MR010778 Zanubrutinib Metabolite M3/M11 Zanubrutinib Metabolite M2 Unclear - Unclear zanubrutinib [8]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010786 Naloxone Metabolite M2 Naloxone Metabolite M35 Unclear - Unclear Naloxone [7]
MR010780 Zanubrutinib Metabolite M2 Zanubrutinib Metabolite M1 Unclear - Unclear zanubrutinib [8]
References
1 Metabolism and Disposition of Prescription Opioids: A Review
2 Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54.
3 Enzalutamide Reduces Oxycodone Exposure in Men with Prostate Cancer. Clin Pharmacokinet. 2023 May 10. doi: 10.1007/s40262-023-01255-1.
4 Impact of genetic variation in CYP2C19, CYP2D6, and CYP3A4 on oxycodone and its metabolites in a large database of clinical urine drug tests. Pharmacogenomics J. 2022 Feb;22(1):25-32. doi: 10.1038/s41397-021-00253-5.
5 Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87.
6 DrugBank(Pharmacology-Metabolism)Oxycodone hydrochloride
7 Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
8 In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

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