Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001886)
Formula
CYP3A4 ...
SVG example
N-Demethylation
Reactant Oxymorphone Product Noroxymorphone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001903 Oxymorphone 6beta-Oxycodol Reduction - 6-Ketoreduction Oxymorphone [1]
MR001904 Oxymorphone 6beta-Oxymorphol Oxidation - N-Demethylation Oxymorphone [1]
MR001902 Oxymorphone Alpha-Oxycodol Reduction - 6-Ketoreduction Oxymorphone [1]
MR001901 Oxymorphone Beta-noroxycodol Oxidation - N-Demethylation Oxymorphone [1]
MR001900 Oxymorphone Nor-6alpha-Oxycodol Oxidation - N-Demethylation Oxymorphone [1]
MR001899 Oxymorphone Noroxycodone Oxidation - N-Demethylation Oxymorphone [1]
MR001905 Oxymorphone Oxymorphone Oxidation - O-Demethylation Oxymorphone [1]
MR001887 Oxymorphone 6beta-Oxymorphol Reduction - 6-Ketoreduction Oxycodone hydrochloride [2]
MR001885 Oxymorphone Hydromorphinol Reduction - 6-Ketoreduction Oxycodone hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010785 Naloxone Naloxone Metabolite M2 Unclear - Unclear Naloxone [3]
MR001878 Noroxycodone Noroxymorphone Oxidation - N-Demethylation Oxycodone hydrochloride [4], [5]
MR013819 Noroxycodone Noroxymorphone Unclear - Unclear Oxycodone [6]
MR010778 Zanubrutinib Metabolite M3/M11 Zanubrutinib Metabolite M2 Unclear - Unclear zanubrutinib [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010786 Naloxone Metabolite M2 Naloxone Metabolite M35 Unclear - Unclear Naloxone [3]
MR010780 Zanubrutinib Metabolite M2 Zanubrutinib Metabolite M1 Unclear - Unclear zanubrutinib [7]
References
1 Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87.
2 DrugBank(Pharmacology-Metabolism)Oxycodone hydrochloride
3 Optimization of Mass Spectrometry Imaging for Drug Metabolism and Distribution Studies in the Zebrafish Larvae Model: A Case Study with the Opioid Antagonist Naloxone
4 Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004 Apr;32(4):447-54.
5 Enzalutamide Reduces Oxycodone Exposure in Men with Prostate Cancer. Clin Pharmacokinet. 2023 May 10. doi: 10.1007/s40262-023-01255-1.
6 Metabolism and Disposition of Prescription Opioids: A Review
7 In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

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