Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002039)
Formula
SVG example
Reactant Pimozide Product 4,4-bis(4-fluorophenyl) butyric acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002040 Pimozide 5-hydroxypimozide Oxidation - Hydroxylation Pimozide [1]
MR002041 Pimozide 6-hydroxypimozide Oxidation - Hydroxylation Pimozide [1]
MR002038 Pimozide DHBPI Oxidation - N-Dealkylation Pimozide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007201 Fluspirilene 4,4-Bis(4-Fluorophenyl)Butanoic Acid Unclear Fluspirilene [2]
MR011140 Penfluridol Penfluridol A1 Oxidation - Oxidation Penfluridol [3]
MR007200 Fluspirilene M1 4,4-Bis(4-Fluorophenyl)Butanoic Acid Unclear Fluspirilene [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007202 4,4-Bis(4-Fluorophenyl)Butanoic Acid 2,2-Bis(4-Fluorophenyl)Acetic Acid Unclear Fluspirilene [2]
References
1 The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites Drug Metab Dispos. 2020 Nov;48(11):1113-1120. doi: 10.1124/dmd.120.000188.
2 The excretion and metabolism of the long-acting neuroleptic drug fluspirilene in the rat
3 Penfluridol: a neuroleptic drug designed for long duration of action

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