Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002038)
Formula
CYP2D6 ...
SVG example
N-Dealkylation
Reactant Pimozide Product DHBPI
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002039 Pimozide 4,4-bis(4-fluorophenyl) butyric acid Unclear Pimozide [1]
MR002040 Pimozide 5-hydroxypimozide Oxidation - Hydroxylation Pimozide [2]
MR002041 Pimozide 6-hydroxypimozide Oxidation - Hydroxylation Pimozide [2]
References
1 LABEL:IMOZIDE tablet
2 The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites Drug Metab Dispos. 2020 Nov;48(11):1113-1120. doi: 10.1124/dmd.120.000188.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.