Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002040)
Formula
SVG example
Hydroxylation
Reactant Pimozide Product 5-hydroxypimozide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002039 Pimozide 4,4-bis(4-fluorophenyl) butyric acid Unclear Pimozide [1]
MR002041 Pimozide 6-hydroxypimozide Oxidation - Hydroxylation Pimozide [2]
MR002038 Pimozide DHBPI Oxidation - N-Dealkylation Pimozide [2]
References
1 LABEL:IMOZIDE tablet
2 The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites Drug Metab Dispos. 2020 Nov;48(11):1113-1120. doi: 10.1124/dmd.120.000188.

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