Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002170)
Formula
SVG example
Hydroxylation
Reactant Progesterone Product 16alpha-hydroxyprogesterone
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002172 Progesterone 11-deoxycorticosterone Oxidation - Hydroxylation Progesterone [1]
MR002173 Progesterone 17-OH progesterone Oxidation - Hydroxylation Progesterone [1]
MR002175 Progesterone 20 a hydroxy- delta 4 a- prenolone Oxidation - Hydroxylation Progesterone [2]
MR002176 Progesterone 2alpha-hydroxyprogesterone Oxidation - Hydroxylation Progesterone [3]
MR002174 Progesterone 5 alpha-dihydroprogesterone Unclear Progesterone [1]
MR002171 Progesterone 6beta-hydroxyprogesterone Oxidation - Hydroxylation Progesterone [1], [3]
MR002178 Progesterone Pregnanediol Oxidation - Hydroxylation Progesterone [4]
MR002179 Progesterone Pregnanetriol Oxidation - Hydroxylation Progesterone [4]
MR002177 Progesterone Pregnanolone Oxidation - Hydroxylation Progesterone [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002844 Dydrogesterone 16alpha-hydroxyprogesterone Unclear Dydrogesterone [5]
References
1 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
2 DrugBank(Pharmacology-Metabolism)Progesterone
3 Progesterone Metabolites Produced by Cytochrome P450 3A Modulate Uterine Contractility in a Murine Model Reprod Sci. 2015 Dec;22(12):1577-86. doi: 10.1177/1933719115589414.
4 FDA:Progesterone
5 Dydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes Xenobiotica. 2016 Oct;46(10):868-74. doi: 10.3109/00498254.2015.1134852.

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