Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002204)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Quetiapine fumarate Product 7-hydroxyquetiapine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002203 Quetiapine fumarate N-desalkylquetiapine Unclear Quetiapine fumarate [1], [2]
MR002206 Quetiapine fumarate O-desalkylquetiapine Oxidation - N-Dealkylation Quetiapine fumarate [1]
MR002205 Quetiapine fumarate Quetiapine sulfoxide Oxidation - Sulfoxidation Quetiapine fumarate [1]
References
1 Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug Metab Dispos. 2009 Feb;37(2):254-8.
2 Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro. Drug Metab Dispos. 2012 Sep;40(9):1778-84.

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