Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002251)
Formula Reactant Sibutramine Product Sibutramine metabolite M2
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002250 Sibutramine Sibutramine metabolite M1 Oxidation - Demethylation Sibutramine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002249 Sibutramine metabolite M2 Sibutramine metabolite M6 Oxidation - Hydroxylation; Conjugation Sibutramine [1], [2]
References
1 Sibutramine: a serotonin-norepinephrine reuptake-inhibitor for the treatment of obesity. Ann Pharmacother. 1999 Sep;33(9):968-78.
2 Metabolic analysis of the illegal analogues of anti-obesity drugs using LC-Q-TOF-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jan 15;1163:122502. doi: 10.1016/j.jchromb.2020.122502.

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