Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002313)
Formula Reactant Suvorexant Product hydroxyl-suvorexant
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydoxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002315 Suvorexant Suvorexant metabolite M10a Oxidation - Hydoxylation Suvorexant [1], [2]
MR002316 Suvorexant Suvorexant metabolite M17 Unclear Suvorexant [2]
MR002314 Suvorexant Suvorexant metabolite M8 Oxidation - Hydoxylation Suvorexant [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002308 hydroxyl-suvorexant Suvorexant metabolite M4 Oxidation - Oxidation Suvorexant [1], [2]
References
1 CYP450-Mediated metabolism of suvorexant and investigation of metabolites in forensic case specimens Forensic Sci Int. 2020 Jul;312:110307. doi: 10.1016/j.forsciint.2020.110307.
2 In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans Xenobiotica. 2016 Oct;46(10):882-95. doi: 10.3109/00498254.2015.1129565.

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