Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002314)
Formula
SVG example
Hydoxylation
Reactant Suvorexant Product Suvorexant metabolite M8
Reactant Info Product Info
Metabolic Type Oxidation - Hydoxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002313 Suvorexant hydroxyl-suvorexant Oxidation - Hydoxylation Suvorexant [1], [2], [3]
MR002315 Suvorexant Suvorexant metabolite M10a Oxidation - Hydoxylation Suvorexant [2], [3]
MR002316 Suvorexant Suvorexant metabolite M17 Unclear Suvorexant [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002311 Suvorexant metabolite M8 Suvorexant metabolite M3 Conjugation - Glucuronidation Suvorexant [3]
References
1 Suvorexant: a promising, novel treatment for insomnia. Neuropsychiatr Dis Treat. 2016 Feb 25;12:491-5.
2 CYP450-Mediated metabolism of suvorexant and investigation of metabolites in forensic case specimens Forensic Sci Int. 2020 Jul;312:110307. doi: 10.1016/j.forsciint.2020.110307.
3 In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans Xenobiotica. 2016 Oct;46(10):882-95. doi: 10.3109/00498254.2015.1129565.

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