Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002443)
Formula
SVG example
Hydroxylation
Reactant Trazodone hydrochloride Product 4'-hydroxytrazodone
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002444 Trazodone hydrochloride M-chlorophenylpiperazine Oxidation - N-Dealkylation Trazodone hydrochloride [1]
MR002442 Trazodone hydrochloride Triazolopyridinone epoxide Unclear Trazodone hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002440 4'-hydroxytrazodone Trazodone hydrochloride M6 Conjugation - Glutathione Conjugation Trazodone hydrochloride [2]
MR002441 4'-hydroxytrazodone Trazodone hydrochloride MW Unclear Trazodone hydrochloride [2]
References
1 Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats Int J Neuropsychopharmacol. 1999 Mar;2(1):17-23. doi: 10.1017/S1461145799001303.
2 Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4. Chem Biol Interact. 2005 Jun 30;155(1-2):10-20.

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