Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002444)
Formula
SVG example
N-Dealkylation
Reactant Trazodone hydrochloride Product M-chlorophenylpiperazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002443 Trazodone hydrochloride 4'-hydroxytrazodone Oxidation - Hydroxylation Trazodone hydrochloride [1]
MR002442 Trazodone hydrochloride Triazolopyridinone epoxide Unclear Trazodone hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013453 Etoperidone 1-(3-chlorophenyl) piperazine Unclear Etoperidone [2], [3]
MR004891 Nefazodone M-Chlorophenylpiperazine Unclear Nefazodone [4]
MR004886 Hydroxynefazodone M-Chlorophenylpiperazine Unclear Nefazodone [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013454 1-(3-chlorophenyl) piperazine Etoperidone Metabolite N9 Oxidation - N-dealkylation Etoperidone [2]
MR004887 M-Chlorophenylpiperazine p-hydroxy-mCPP Unclear Nefazodone [4]
References
1 Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4. Chem Biol Interact. 2005 Jun 30;155(1-2):10-20.
2 Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man
3 In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica. 2002 Nov;32(11):949-62.
4 Clinical pharmacokinetics of nefazodone. Clin Pharmacokinet. 1997 Oct;33(4):260-75.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.