Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002502)
Formula
SVG example
N-Demethylation
Reactant Vandetanib Product N-desmethyl vandetanib
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002503 Vandetanib Vandetanib N-oxide Oxidation - Oxidation Vandetanib [1], [2]
References
1 Pharmacokinetics of vandetanib: three phase I studies in healthy subjects Clin Ther. 2012 Jan;34(1):221-37. doi: 10.1016/j.clinthera.2011.11.011.
2 Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation Int J Mol Sci. 2019 Jul 10;20(14):3392. doi: 10.3390/ijms20143392.

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