Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002503)
Formula
FMO1 ...
SVG example
Oxidation
Reactant Vandetanib Product Vandetanib N-oxide
Reactant Info Product Info
Metabolic Enzyme Dimethylaniline oxidase 1 (FMO1) DME Info
Dimethylaniline oxidase 3 (FMO3) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002502 Vandetanib N-desmethyl vandetanib Oxidation - N-Demethylation Vandetanib [1], [2], [3]
References
1 Pharmacokinetics of vandetanib: three phase I studies in healthy subjects Clin Ther. 2012 Jan;34(1):221-37. doi: 10.1016/j.clinthera.2011.11.011.
2 Functional evaluation of vandetanib metabolism by CYP3A4 variants and potential drug interactions in vitro Chem Biol Interact. 2021 Dec 1;350:109700. doi: 10.1016/j.cbi.2021.109700.
3 Identification of Human Enzymes Oxidizing the Anti-Thyroid-Cancer Drug Vandetanib and Explanation of the High Efficiency of Cytochrome P450 3A4 in its Oxidation Int J Mol Sci. 2019 Jul 10;20(14):3392. doi: 10.3390/ijms20143392.

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